Sexual dimorphism in Parkinson’s disease: differences in clinical manifestations, quality of life and psychosocial functioning between males and females
Identifieur interne : 000028 ( Main/Exploration ); précédent : 000027; suivant : 000029Sexual dimorphism in Parkinson’s disease: differences in clinical manifestations, quality of life and psychosocial functioning between males and females
Auteurs : Farzaneh Farhadi ; Kia Vosoughi ; Gholam Ali Shahidi [Iran] ; Ahmad Delbari [Suède, Iran] ; Johan Lökk [Suède] ; Seyed-Mohammad Fereshtehnejad [Suède, Canada, Iran]Source :
- Neuropsychiatric Disease and Treatment [ 1176-6328 ] ; 2017.
Abstract
Sex-related differences in clinical manifestations and consequences of Parkinson’s disease (PD) have been poorly explored. Better understanding of sexual dimorphism in neurologic diseases such as PD has been announced as a research priority. The aim of our study was to determine independent sex differences in clinical manifestations and subtypes, psychosocial functioning, quality of life (QoL) and its domains between male and female individuals with PD.
A comprehensive list of demographics, motor symptoms and subtypes, nonmotor features, health-related quality of life (HRQoL), psychosocial functioning and general aspects of daily life was assessed in 157 individuals (108 males and 49 females) with idiopathic PD. In order to control for potential confounding variables, we applied Orthogonal Partial Least Squares – Discriminant Analysis (OPLS-DA) to explore the strength of each feature to discriminate male and female patients with PD.
While no sex difference was found in the total Unified Parkinson’s Disease Rating Scale (UPDRS) score and cumulative daily dose of levodopa, females had significantly more severe anxiety (mean difference =2.2 [95% confidence interval, CI: 0.5–4.0],
Our study provides a comprehensive understanding of sexual dimorphism in PD. Anxiety, depression, specific domains of HRQoL (mobility, emotional well-being, social support and bodily discomfort) and psychosocial functioning were significantly worse in female individuals with PD. Sexual dimorphism in PD highlights the features that are more likely to be affected in each sex and should be specifically targeted when managing male and female individuals with PD.
Url:
DOI: 10.2147/NDT.S124984
PubMed: 28203083
PubMed Central: 5295791
Affiliations:
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sortKey="Shahidi, Gholam Ali" sort="Shahidi, Gholam Ali" uniqKey="Shahidi G" first="Gholam Ali" last="Shahidi">Gholam Ali Shahidi</name><affiliation wicri:level="1"><nlm:aff id="af2-ndt-13-329">Movement Disorders Clinic, Department of Neurology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Movement Disorders Clinic, Department of Neurology, Faculty of Medicine, Iran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Delbari, Ahmad" sort="Delbari, Ahmad" uniqKey="Delbari A" first="Ahmad" last="Delbari">Ahmad Delbari</name><affiliation wicri:level="3"><nlm:aff id="af3-ndt-13-329">Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Clinical Geriatrics, 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Care Sciences, and Society (NVS), Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="af6-ndt-13-329">Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, McGill University, Montreal, QC</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af7-ndt-13-329">Firoozgar Clinical Research Development Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Firoozgar Clinical Research Development Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neuropsychiatric Disease and Treatment</title><idno type="ISSN">1176-6328</idno><idno type="eISSN">1178-2021</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>Sex-related differences in clinical manifestations and consequences of Parkinson’s disease (PD) have been poorly explored. Better understanding of sexual dimorphism in neurologic diseases such as PD has been announced as a research priority. The aim of our study was to determine independent sex differences in clinical manifestations and subtypes, psychosocial functioning, quality of life (QoL) and its domains between male and female individuals with PD.</p></sec><sec><title>Patients and methods</title><p>A comprehensive list of demographics, motor symptoms and subtypes, nonmotor features, health-related quality of life (HRQoL), psychosocial functioning and general aspects of daily life was assessed in 157 individuals (108 males and 49 females) with idiopathic PD. In order to control for potential confounding variables, we applied Orthogonal Partial Least Squares – Discriminant Analysis (OPLS-DA) to explore the strength of each feature to discriminate male and female patients with PD.</p></sec><sec><title>Results</title><p>While no sex difference was found in the total Unified Parkinson’s Disease Rating Scale (UPDRS) score and cumulative daily dose of levodopa, females had significantly more severe anxiety (mean difference =2.2 [95% confidence interval, CI: 0.5–4.0], <italic>P</italic>=0.011), worse nutritional status (23.8 [standard deviation, SD =4.2] vs 25.8 [SD =2.6], <italic>P</italic>=0.003) and poorer QoL (28.3 [SD =15.7] vs 17.9 [SD =14.2], <italic>P</italic><0.001). Based on multivariate discriminant analysis, emotional well-being, bodily discomfort, social support, mobility and communication domains of HRQoL, together with anxiety, depression and psychosocial functioning, were the strongest features with more severe/worse status in females after adjustment for potential statistical confounders.</p></sec><sec><title>Conclusion</title><p>Our study provides a comprehensive understanding of sexual dimorphism in PD. Anxiety, depression, specific domains of HRQoL (mobility, emotional well-being, social support and bodily discomfort) and psychosocial functioning were significantly worse in female individuals with PD. Sexual dimorphism in PD highlights the features that are more likely to be affected in each sex and should be specifically targeted when managing male and female individuals with PD.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Langston, Jw" uniqKey="Langston J">JW Langston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elbaz, A" uniqKey="Elbaz A">A Elbaz</name></author><author><name sortKey="Bower, Jh" uniqKey="Bower J">JH Bower</name></author><author><name sortKey="Maraganore, Dm" uniqKey="Maraganore D">DM Maraganore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pavon, Jm" uniqKey="Pavon J">JM Pavon</name></author><author><name sortKey="Whitson, He" uniqKey="Whitson H">HE Whitson</name></author><author><name sortKey="Okun, Ms" uniqKey="Okun M">MS Okun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stuendl, A" 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Breteler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Letenneur, L" uniqKey="Letenneur L">L Letenneur</name></author><author><name sortKey="Gilleron, V" uniqKey="Gilleron V">V Gilleron</name></author><author><name sortKey="Commenges, D" uniqKey="Commenges D">D Commenges</name></author><author><name sortKey="Helmer, C" uniqKey="Helmer C">C Helmer</name></author><author><name sortKey="Orgogozo, Jm" uniqKey="Orgogozo J">JM Orgogozo</name></author><author><name sortKey="Dartigues, Jf" uniqKey="Dartigues J">JF Dartigues</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shin, Jy" uniqKey="Shin J">JY Shin</name></author><author><name sortKey="Pohlig, Rt" uniqKey="Pohlig R">RT Pohlig</name></author><author><name sortKey="Habermann, B" uniqKey="Habermann B">B Habermann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scaglione, C" uniqKey="Scaglione C">C Scaglione</name></author><author><name sortKey="Vignatelli, L" uniqKey="Vignatelli L">L Vignatelli</name></author><author><name sortKey="Plazzi, G" uniqKey="Plazzi G">G Plazzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ozekmekci, S" uniqKey="Ozekmekci S">S Ozekmekci</name></author><author><name sortKey="Apaydin, H" uniqKey="Apaydin H">H Apaydin</name></author><author><name sortKey="Kilic, E" uniqKey="Kilic E">E Kilic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoritaka, A" uniqKey="Yoritaka A">A Yoritaka</name></author><author><name sortKey="Ohizumi, H" uniqKey="Ohizumi H">H Ohizumi</name></author><author><name sortKey="Tanaka, S" uniqKey="Tanaka S">S Tanaka</name></author><author><name sortKey="Hattori, N" uniqKey="Hattori N">N Hattori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pandey, S" uniqKey="Pandey S">S Pandey</name></author><author><name sortKey="Bajaj, Bk" uniqKey="Bajaj B">BK Bajaj</name></author><author><name sortKey="Wadhwa, A" uniqKey="Wadhwa A">A Wadhwa</name></author><author><name sortKey="Anand, Ks" uniqKey="Anand K">KS Anand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Den Eeden, Sk" uniqKey="Van Den Eeden S">SK Van Den Eeden</name></author><author><name sortKey="Tanner, Cm" uniqKey="Tanner C">CM Tanner</name></author><author><name sortKey="Bernstein, Al" uniqKey="Bernstein A">AL Bernstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalia, Lv" uniqKey="Kalia L">LV Kalia</name></author><author><name sortKey="Lang, Ae" uniqKey="Lang A">AE Lang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>Iran</li><li>Suède</li></country><region><li>Québec</li><li>Svealand</li></region><settlement><li>Montréal</li><li>Stockholm</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><noCountry><name sortKey="Farhadi, Farzaneh" sort="Farhadi, Farzaneh" uniqKey="Farhadi F" first="Farzaneh" last="Farhadi">Farzaneh Farhadi</name><name sortKey="Vosoughi, Kia" sort="Vosoughi, Kia" uniqKey="Vosoughi K" first="Kia" last="Vosoughi">Kia Vosoughi</name></noCountry><country name="Iran"><noRegion><name sortKey="Shahidi, Gholam Ali" sort="Shahidi, Gholam Ali" uniqKey="Shahidi G" first="Gholam Ali" last="Shahidi">Gholam Ali Shahidi</name></noRegion><name sortKey="Delbari, Ahmad" sort="Delbari, Ahmad" uniqKey="Delbari A" first="Ahmad" last="Delbari">Ahmad Delbari</name><name sortKey="Fereshtehnejad, Seyed Mohammad" sort="Fereshtehnejad, Seyed Mohammad" uniqKey="Fereshtehnejad S" first="Seyed-Mohammad" last="Fereshtehnejad">Seyed-Mohammad Fereshtehnejad</name></country><country name="Suède"><region name="Svealand"><name sortKey="Delbari, Ahmad" sort="Delbari, Ahmad" uniqKey="Delbari A" first="Ahmad" last="Delbari">Ahmad Delbari</name></region><name sortKey="Fereshtehnejad, Seyed Mohammad" sort="Fereshtehnejad, Seyed Mohammad" uniqKey="Fereshtehnejad S" first="Seyed-Mohammad" last="Fereshtehnejad">Seyed-Mohammad Fereshtehnejad</name><name sortKey="Lokk, Johan" sort="Lokk, Johan" uniqKey="Lokk J" first="Johan" last="Lökk">Johan Lökk</name><name sortKey="Lokk, Johan" sort="Lokk, Johan" uniqKey="Lokk J" first="Johan" last="Lökk">Johan Lökk</name></country><country name="Canada"><region name="Québec"><name sortKey="Fereshtehnejad, Seyed Mohammad" sort="Fereshtehnejad, Seyed Mohammad" uniqKey="Fereshtehnejad S" first="Seyed-Mohammad" last="Fereshtehnejad">Seyed-Mohammad Fereshtehnejad</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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